Dr. Benjamin D. Levine:

Up Dr. Babb Dr. Crandall Dr. Haller Dr. Qi Fu Dr. Levine Dr. Martin Dr. Stone Dr. Zhang 

BIOGRAPHICAL SKETCH

NAME

Benjamin David Levine, M.D.

POSITION TITLE

Professor of Medicine

EDUCATION /TRAINING 

INSTITUTION AND LOCATION

DEGREE

YEAR(s)

FIELD OF STUDY

Brown University, Providence, Rhode Island

BA

1978

Biology

Harvard Medical School, Boston, MA

MD

1982

Medicine

Stanford University Medical Center, Stanford, CA

Resident

1985

Medicine

Shinshu University, Matsumoto, Japan

Fellow

1986

Env. Physiol

UT Southwestern Medical Center, Dallas, Texas

Fellow

1989

Cardiology

 

PROFESSIONAL EXPERIENCE:

1986-87 Staff Physician, Himalayan Rescue Association, Pheriche, Nepal

1989- Medical Director, Cardiac Rehabilitation, Parkland Memorial Hospital, and Cardiovascular Health and Risk Modification Program, James W. Aston Center, University of Texas Southwestern Medical Center

1990-96 Assistant Professor, Department of Medicine, Division of Cardiology, University of Texas Southwestern Medical Center, Dallas, Texas

1992- Director, Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas and University of Texas Southwestern Medical Center, Dallas, Texas

1998- Unit Director, Cardiovascular Section, NASA Specialized Center of Research and Training (Director C. Gunnar Blomqvist, M.D., Ph.D.)

1996 – Human Research Facility (Space Station) ScientificWorking Group

1996-99 NASA Minority University Research & Education Division Research Center Grants Advisory Committee

1997-02 Associate Professor, Department of Medicine, Division of Cardiology, University of Texas Southwestern Medical Center, Dallas, Texas

1998- National Space Biology Research Institute Board of Scientific Counselors

2002- Professor, Department of Medicine, Division of Cardiology, University of Texas Southwestern Medical Center, Dallas, Texas

2004- Center for Scientific Review NIH/NHLBI
Clinical Intergrative Cardiovascular Sciences
(CICS) Study Section

2005 - Board of Directors of the American Autonomic Society.

2006 -  Board of Trustees of the American College of Sports Medicine

 

HONORS:  Phi Beta Kappa, 1977; Magna Cum Laude in human biology, 1978; Henry Luce Foundation Scholar, 1985-86; Fulbright Scholar, 1989; William O. Moseley Scholar, 1989 and 1999; Fellow, American College of Cardiology, 1991; Fellow, American College of Sports Medicine,1995; S. Finley Ewing Jr. Chair for Wellness at Presbyterian Hospital 1995; van Handel memorial award, US Olympic Committee, 1996; Wilderness Medical Society Research Award, 1998; Nominated IOC Olympic Scientific Medal, 1999; Harry S. Moss Heart Chair in Cardiovascular Research, 1999; President's Lecture at American College of Sports Medicine (ACSM), 2000, Keynote Address at International Olympic Committee Scientific Congress, 2002; ACSM Texas Chapter Honor Award and Raven Lecture, 2005; ACSM John Sutton Lectureship 2006.  Service: Human Subjects Institutional Review Board 1997-; GCRC Executive Committee 1995-, American Heart Association, committee on Physical Activity 2003 - ; ACSM-National Program Committee, Research Awards Committee; Texas ACSM Regional Board Member 1995-98, Editorial Board, Journal of Applied Physiology, 1999 - 2001; High Altitude Medicine & Biology, 2000 -, Assoc. Editor Med. & Sci. in Sports & Exercise, 2000 – 2004,2006 American College of Sports Medicine (National) 1st John Sutton Memorial Clinical Lectureship, 2006 Michael J. Joyner Teaching Award, Royal Danish Academy of Cardiovascular Sciences, 2007 American College of Sports Medicine (National) Citation Award.

REPRESENTATIVE PUBLICATIONS:                  (Total 108 published)                                                                         

1. May DC, Popma JJ, Black WH, Schaefer S, Lee HR, Levine BD, Hillis LD. In vivo induction and reversal of nitroglycerin tolerance in human coronary arteries. N Engl J Med 317:805-809, 1987.

2. Levine BD, Kubo K, Kobayashi T, Fukushima M, Shibamoto T, Ueda, G. The role of barometric pressure in pulmonary fluid balance and oxygen transport. J Appl Physiol 64:419-428, 1988.

3. Schaefer S, Taylor AL, Lee HR, Niggemann EH, Levine BD, Popma JJ, Mitchell JH, Hillis LD. The effect of increasing heart rate on left ventricular performance in patients with normal cardiac function. Am J Cardiol 61:617-620, 1988.

 4. Kowashima A, Fujimoto K, Matsuzawa Y, Fukushima M, Kubo K, Levine BD, Kobayashi T, Kusama S. Acute mountain sickness (AMS) in subjects susceptible to high-altitude pulmonary edema. High Altitude Medical Science, Ueda G, Kusama S, Voelkel NF, ed., Shinshu Univ. Press, Matsumoto, Japan, P. 269-273, 1988.

5. Fujimoto K, Kobayashi T, Koyama S, Shibamoto T, Fukushima M, Levine BD, Kusama S. Sleep at high altitude in high altitude pulmonary edema susceptible subjects. High Altitude Medical Science, Ueda G, Kusama S, Voelkel NF, ed., Shinshu Univ. Press, Matsumoto, Japan, p. 313-317, 1988.  

6. Kobayashi T, Koyama S, Kubo K, Fukushima M, Yoshimura K, Shibamoto T, Kitazawa K, Kobayashi H, Fujimoto K, Hirai K, Seki T, Kowashima A, Yagi H, Toyofuku T, Yoshikawa S, Levine BD, et.al. Susceptibility of high altitude pulmonary edema (HAPE); field study in subjects with a history of HAPE. High Altitude Medical Science, Ueda G, Kusama S, Voelkel NF, ed., Shinshu Univ. Press, Matsumoto, Japan, p. 269-273, 1988.

7. Levine BD, Yoshimura K, Kobayashi T, Fukushima M, Shibamoto T, Ueda G. Dexamethasone in the treatment of acute mountain sickness. N Engl J Med 321:1707-1713, 1989. 

 8. Grayburn PA, Pryor SL, Levine, BD, Klein MN., Taylor AL. Day-to-day variability in the size of Doppler color flow jets in mitral regurgitation. Jour Am Col Card 14:936-940, 1989. 

 9. Kremers MS, Levine BD, Spielberger R, Passos-Coelho J. Auto-entrainment of ventricular tachycardia by sinus rhythm. Pace 12:1660-1666, 1989.  

10. Fujimoto K, Matsuzawa Y, Hirai K, Yagi H, Fukushina M, Shibamoto T, Koyama S, Levine BD, Kobayashi T. Irregular nocturnal breathing patterns at high altitude in subjects susceptible to high-altitude pulmonary edema (HAPE): a preliminary study. Aviat Space Environ Med 60:786-791, 1989. 

11. Levine BD, Buckey JC, Fritsch JM, Yancy CW, Watenpaugh DE, Eckberg DL, Blomqvist CG. Physical fitness and cardiovascular regulation: mechanisms of orthostatic intolerance. J Appl Physiol 70:112-122, 1991.

12. Levine BD, Grayburn PA, Voyles WF, Green ER, Roach RC, Hackett PH. Intracardiac shunting across a patent foramen ovale may exacerbate hypoxemia in high-altitude pulmonary edema. Ann Int Med 114:569-570, 1991.

13. Levine BD, Lane LD, Buckey JC, Friedman DB, Blomqvist CG. Left ventricular pressure-volume and Frank-Starling relations in endurance athletes: implications for orthostatic tolerance and exercise performance. Circulation, 84:1016-1023, 1991. 

14. Levine BD, Friedman DB, Engfred K, Hanel B, Kjaer M, Clifford PS, Secher NH. The effect of normoxic or hypobaric hypoxic endurance training on the hypoxic ventilatory response. Med Sci Sports Exercise 24:769-775, 1992.  

15. Hackett PH, Roach RC, Hartig GS, Greene ER, Levine BD. The effect of vasodilators on pulmonary hemodynamics in high altitude pulmonary edema: a comparison. Int J Sports Med 13(S1):S68-S71, 1992.

16. Giller C, Levine BD, Meyer Y, Buckey JC, Lane LD, Borchers DJ. The cerebral hemodynamics of normotensive hypovolemia during lower body negative pressure. J Neurosurgery 76:961-966, 1992.

17. Alexander T, Friedman DB, Levine BD, Pawelczyk JA, Mitchell JH. Cardiovascular responses during static exercise: studies in patients with complete heart block and dual chamber pacemakers. Circulation 89:1643-1647, 1994. 

18. Levine BD, Giller CA, Lane LD, Buckey JC, Blomqvist CG. Cerebral vs systemic hemodynamics during graded orthostatic stress in humans. Circulation 90:298-306, 1994. 

19. Engfred K, Kjaer M, Secher NH, Friedman DB, Hanel B, Nielsen OJ, Bach FW, Galbo H, Levine BD. Hypoxia and training-induced adaptation of hormonal responses to exercise in humans. European J Appl Physiol, 68(4):303-9, 1994. 

20. Hanel B, Levine BD, Engfred K, Clifford PS, Friedman DB, Secher NH. Maximal inspiratory pressure following endurance training at altitude. Ergonomics 37(1):59-67, 1994.

21. Blomqvist CG, Buckey JC, Gaffney FA, Lane LD, Levine BD, Watenpaugh DE. Mechanisms of post-flight orthostatic intolerance. Journal of Gravitational Physiology 1:122-124, 1994. 

22. Buckey JC, Lane LD, Levine BD, Watenpaugh DE, Wright SJ, Moore WE, Gaffney FA, Blomqvist CG.  Orthostatic intolerance after spaceflight. J Appl Physiol 81:1:7-18, 1996.

23. Buckey JC, Gaffney FA, Lane LD, Levine BD, Watenpaugh DE, Wright SJ, Yancy CW Jr., Blomqvist CG. Central venous pressure in space. J Appl Physiol 81(1):19-25, 1996.

24. Levine BD, Lane LD, Watenpaugh DE, Gaffney FA, Buckey JC, Blomqvist CG. Maximal exercise performance after adaptation to microgravity. J Appl Physiol 81(2):686-694, 1996.

25. Gordon NF, Scott CB, Levine BD. Comparison of single versus multiple lifestyle interventions: are the antihypertensive effects of exercise training and diet-induced weight loss additive? Am J Cardiol, 79(7):763-767, 1997. 

26. Levine BD, Stray-Gundersen J. Living-high training low: effect of moderate-altitude acclimatization with low-altitude training on performance. J Appl Physiol, 83(1):102-112, 1997. 

27. Levine BD, Zuckerman JH, Pawelczyk JA. Cardiac atrophy after bedrest deconditioning: a non-neural mechanism for orthostatic intolerance. Circulation 96(2):517-525, 1997.

28. Friedman DB, Williams AN, Levine BD. Compliance and efficacy of cardiac rehabilitation and risk factor modification in the medically indigent. Am Journal of Cardiol 79:281-285, 1997.

29. Levine BD, Zuckerman JH, deFilippi CR. The effect of high altitude exposure in the elderly: the tenth mountain division study. Circulation 96:1224-1232, 1997. 

30. Zhang R, Zuckerman JH, Pawelczyk JA, Levine BD. Effects of head-down tilt bed rest on cerebral hemodynamics during orthostatic stress. J Appl Physiol, 83(6):2139-2145, 1997.

31. Zhang R, Zuckerman JH, Giller CA, Levine BD. Transfer function analysis of dynamic cerebral autoregulation in humans. Am J Physiol, 274 (Heart Cir. Physiol. 43):H233-H241, 1998.

32. King AC, Sallis JF, Dunn AL, Simons-Morton DG, Albright CA, Cohen S, Rejeski WJ, Marcus BH, and Coday MC for the Activity Counseling Trial Research Group. Overview of the Activity Counseling Trial (ACT) intervention for promoting physical activity in primary health care settings. Med Sci Sports Exerc, V30 7:1086-1096, 1998.

33. Blair SN, Applegate WB, Dunn AL, Ettinger WH, Haskell W, King AC, Morgan TM, Shih JH, and Simons-Morton DG for the Activity Counseling Trial Research Group. Activity Counseling Trial (ACT) rationale, design, and method. Med Sci Sports Exerc, v30 7:1097-1105, 1998.

34. Zhang R, Zuckerman JH, Levine BD. Deterioration of cerebral autoregulation during orthostatic stress: insights from frequency domain analysis. J Appl Physiol 85:1113-1122, 1998.

35. Afridi I, Main ML, Parrish DL, Kizilbash A, Levine BD, Grayburn PA. Usefulness of isometric hand grip exercise in detecting coronary artery disease during dobutamine atropine stress echocardiography in patients with either stable angina pectoris or another type or positive stress test. Am J Cardiol 82:564-568, 1998.

36. Chapman RF, Stray-Gundersen J, Levine BD. Individual variation in response to altitude training. J Appl Physiol 85:1448-1456 , 1998.

37. Crandall CG, Levine BD, Etzell RA. Effect of increasing central venous pressure during passive heating on skin blood flow. Amer J. Physiol 86(2):605-610, 1999.

38. Garcia JA, McMinn SB, Zuckerman JH, Fixler DE, Levine BD. The role of right ventricular function for exercise performance at high altitude: insights from patients after the Fontan operation. Med Sci Sports Exer 31:269-276,1999.

39. West BJ, Zhang R, Sanders AW, Miniyar S, Zuckerman JH, Levine BD. Fractal fluctuations in transcranial Doppler signals. Physical Review E., 59:3, 3492-3498, 1999.

40. West BJ, Zhang R, Sanders AW, Miniyar S, Zuckerman JH, Levine BD. Fractal fluctuations in cardiac time series. Physica A, 270:552-566, 1999.

41. Margitic S, Sevick MA, Miller M, Albright C, Banton J, Callahan K Garcia M, Gibbons L, Levine BD, Anderson R,Ettinger W, for the Activity Counseling Trial Research Group. Challenges Faced in Recruiting Patients from Primary Care Practices into a Physical Activity Intervention Trial. Preventative Medicine 29, 277-286, 1999.

42. Levine BD, Zhang R, and Roach RC. Dynamic cerebral autoregulation at high altitude. Hypoxia Into the Next Millennium. Adv. Exp. Med. 474:319-322, 1999.

43. Cooke WH, Ames JE, Crossman AA, Cox JF, Kuusel TA, Tahvanainen K, Levine BD, Moon B, Blomqvist CG, Eckberg DL.  Nine months in space: the effects on human autonomic cardiovascular regulation. J. Appl. Physiol. 89:1039-1045, 2000. 

44. Crandall CG, Zhang R, and Levine BD. Effects of whole body heating on dynamic baroflex regulation of heart rate in humans. Amer Jour of Physiol, Heart and Circ. Physiol 279:H2486-H2492, 2000.

45. Firstenberg MS, Levine BD, Garcia MJ, et. al. Relationship of echocardiographic indices to pulmonary capillary wedge pressures in healthy volunteers. J Amer College of Cardiology, 36:(5)1664-1669, 2000.

46. Iwasaki K, Zhang R, Zuckerman JH, Pawelczyk JA, Levine BD. Effect of head-down-tilt bed rest and hypovolemia on dynamic regulation of heart rate and blood pressure. Am J Physiol Regulatory, Integrative and Comparative Physiology, 279: R2189-R2199, 2000. 

47. Simons-Morton DG, Hogan P, Dunn AL, Pruitt L, King AC, Levine BD, Miller ST. For the Activity Counseling Trial Research Group. Characteristics of Inactive Primary Care Patients: Baseline Data from the Activity Counseling Trial. Preventive Medicine, 31, 513-521, 2000. 

48. Zhang R, Zuckerman JH, Levine BD. Spontaneous fluctuations in cerebral blood flow velocity: Insights from extended duration recordings in humans. Am J Physiol: Heart and Circulatory Physiology, 278:H1848-H1855, 2000.

49. Zhang R, Behbehani K, Crandall CG, Zuckerman JH, Levine BD. Dynamic regulation of heart rate during acute hypotension: A new insight into baroreflex function. Am J Physiol: Heart and Circ. Physiology, 280:H407-H419, 2001.

50. Watenpaugh DE, Buckey JC, Lane LD, Gaffney FA, Levine BD, Moore WE, Wright SJ, Blomqvist CG. Effects of Space Flight on Human Calf Hemodynamics. Journal of Applied Physiology, Vol. 90, No. 4, 1552-1558, April, 2001.

51. Pawelczyk JA, Zuckerman JH, Blomqvist CG and Levine BD. Regulation of muscle sympathetic nerve activity after bed rest deconditioning. Am J Physiol: Heart and Circulatory Physiology, 280(5):2230-2239, 2001.

52. Perhonen M, Zuckerman JH, Levine BD. Deterioration of left ventricular chamber performance after bed rest: "Cardiovascular deconditioning" or hypovolemia? Circulation, 103:1851-1857, 2001.

53. Perhonen MA, Franco F, Lane LD, Buckey JC, Blomqvist CG, Zerwekh JE, Peshock RM, Weatherall PT, Levine BD. Cardiac atrophy after bed rest and spaceflight. Journal of Applied Physiology, 91:645-653, 2001.

54. Stray-Gundersen J, Chapman RF, Levine BD. "Living High-Training Low" altitude training improves sea level performance in male and female elite runners. Journal of Applied Physiology, 91:1113-1120, 2001.

55. McGuire DK, Levine BD, Williamson JW, Snell PG, Blomqvist CG, Saltin B and Mitchell JH. A 30-Year Follow-Up of the Dallas Bed Rest and Training Study I. Effect of Age on the Cardiovascular Response to Exercise. Circulation 104:1350-1357, 2001, II: Adaptation to Exercise Training. Circulation 104:1358-1366,2001.

56. McGuire DK, Levine BD, Williamson JW, Snell PG, Blomqvist CG, Saltin B and Mitchell JH. A 30-Year Follow-Up of the Dallas Bed Rest and Training Study II. Effect of Age on the Cardiovascular Adaptation to Exercise Training. Circulation 104:1358-1366, 2001.

57. Cole CR, Zuckerman JH, Levine BD. Carotid sinus "irritability" rather than hypersensitivity: a new, more accurate name for an old syndrome. Clinical Autonomic Research, 11:109-113, 2001. 

58. The Writing Group for the Activity Counseling Trial Research Group. Effects of Physical Activity Counseling in Primary Care. The Activity Counseling Trial: A Randomized Controlled Trial. JAMA, Vol. 286, No. 6, 677-687, August 8, 2001.

59. Cox JF, Tahvanainen K, Kuusela TA, Levine BD, Cooke WH, Mano T, Iwase S, Saito M, et. al. Influence of microgravity on astronauts' sympathetic and vagal responses to valsalva's manoeuvre. J Physiol, 538:309-320, 2002.   

60. Ertl AC, Diedrich A, Biaggioni I, Levine BD, Robertson RM, Cox JF, Zuckerman JH, Pawelczyk JA, Ray CA, et. al. Human muscle sympathetic nerve activity and plasma noradrenaline kinetics in space. J Physiol, 538:321-329, 2002. 

61. Levine BD, Pawelczyk JA, Ertl AC, et. al. Human muscle sympathetic neural and haemodynamic responses to tilt following spaceflight. J of Physiol, 538:331-340, 2002.

62. Mitsis GD, Zhang R, Levine BD, Marmarelis VZ. Modeling of nonlinear physiological systems with fast and slow dynamics Part II: Application to cerebral autoregulation in humans. Annals of Biomedical Engineering 30:255-265, 2002.

63. Ge RL, Witkowski S, Zhang Y, Alfrey C, Sivieri M, Karlsen T, Resaland GK, Stray-Gundersen J, and Levine BD. Determinants of erythropoietin release in response to short term, hypobaric hypoxia. J of Applied Physiol, 92:2361-2367, 2002.

64. Pawelczyk JA, and Levine BD. Heterogeneous responses of human limbs to infused adrenergic agonists: a gravitational effect? Journal Appl Physiol; 92:2105-2113, 2002.

65. Zhang R, Zuckerman JH, Iwasaki K, Behbehani K, Crandall CG, Levine BD. Mechanism of Blood Pressure and R-R variability: Insights from Ganglion Blockade in Humans. J Physiol., 543.1, 337-348, 2002.

66. Fu Q, Levine BD, Pawelczyk JA, Ertl AC, Diedrich A, Cox JF, Zuckerman JH, Ray CA, Smith ML, Iwase S, Saito M, Sugiyama Y, Mano T, Zhang R, Iwasaki K, Lane L, Buckey J, Cooke W, Robertson R, Baisch F, Blomqvist G, Eckberg DL, Robertson D, Biaggioni I. Cardiovascular and sympathetic neural responses to handgrip and cold pressor stimuli in humans before, during and after spaceflight. J Physiol., 544.2:653-664, 2002.

67. Cooke WH, Zhang R, Zuckerman JH, Cui J, Wilson TE, Crandall CG, Levine BD. Does nitric oxide buffer arterial blood pressure variability in humans? Journal of Applied Physiology, 93:1466-1470, 2002.

68. Zhang R, Zuckerman JH, Iwasaki K, Wilson TE, Crandall CG, Levine BD. Autonomic Neural Control of Dynamic Cerebral Autoregulation in Humans. Circulation, 106:1814-1820, 2002.

69. Truijens MJ, Toussaint HM, Levine BD. Effect of High-Intensity Hypoxic Training on Sea-Level Swimming Performances. Journal of Applied Physiology, 94:733-743, 2003.

70. Wilson TE, Shibasaki M, Cui J, Levine BD, Crandall CG. Effects of 14 days head-down tilt bed rest on cutaneous vasoconstrictor responses in humans. J. Appl. Physiol, 94:2113-2118, 2003.

71. Ge RL, Chase PJ, Witkowski S, Wyrick BL, Stone JA, Levine BD, Babb TG. Obesity: Associations with Acute Mountain Sickness.  Annals of Internal Medicine, 139:253-258, 2003.

72. Crandall CG, Shibasaki M., Wilson TE, Cui J, Levine BD. Prolonged head-down tilt exposure reduces maximal cutaneous vasodilator and sweating capacity in humans. J Appl Physiol 94:2330-2336, 2003.

73. Iwasaki K, Zhang R, Zuckerman JH, Levine BD. Dose-response relationship of the cardiovascular adaptation to endurance training in healthy adults: How much training for what benefit? Journal of Applied Physiology, 95:1575-1583, 2003.

74. Cheng YJ, Church TS, Kimball TE, Nichaman MZ, Levine BD, Blair SN. Comparison of Coronary Artery Calcium Detected by Electron Beam Tomography in Patients With to Those Without Symptomatic Coronary Heart Disease. American J of Cardiology, 92:498-503, 2003.

75. Jedlickova K, Stockton DW, Chen H, Stray-Gundersen J, Witkowski S, Ge RL, Jelinek J, Levine BD, Prchal JT. Search for Genetic Determinants of Individual Variability of the Erythropoietin Response to High Altitude. Blood Cells, Molecules, and Diseases, 31:175-182, 2003.

76. Cui J, Zhang R, Wilson TE, Witkowski S, Crandall CG, Levine BD. Nitric oxide synthase inhibition does not affect regulation of muscle sympathetic nerve activity during head-up tilt. Journal of Applied Physiology, 285: H2105-H2110, 2003.

77.  Shibasaki M, Wilson T, Cui J, Levine BD, Crandall CG. Exercise throughout 6 degree head down tilt bed rest preserves thermoregulatory responses. J. of Applied Physiology, 95: 1817-1823, 2003.

78.    Zhang R, Wilson TE, Witkowski S, Cui J, Crandall CG, Levine BD.  Inhibition of nitric oxide synthase does not alter dynamic cerebral autoregulation in humans.  AJP:  Heart and Circulatory Physiology, 286:H863-H869, 2004. 

79.    Fu Q, Arbab-Zadeh A, Perhonen MA, Zhang R, Zuckerman JH, Levine BD.  Hemodynamics of orthostatic intolerance:  Implications for gender differences.  American Journal of Physiology:  Heart and Circulatory Physiology, 286:H449-H457, 2004.

 80.    Bleeker MW, De Groot PCE, Pawelczyk JA, Hopman MTE, Levine BD.  Effects of 18 days of bed rest on leg and arm venous properties.  Journal of Applied Physiology, 96: 840 – 847, 2004

 81.    Julian CG, Gore CJ, Wilber RL, Daniels JT, Fredericson M, Stray-Gundersen J, Hahn AG, Parisotto R, Levine BD.  Intermittent Normobaric Hypoxia does not alter Perforrmance or Erythropoietic Markers in Highly Trained Distance Runners. J Appl Physiol, 96: 1800 – 1807, 2004

 82.    Zhang R, Crandall CG, Levne BD.  Cerebral hemodynamics during the Valsalva Maneuver:  Insights from Ganglionic Blockade, Stroke, 35(4):843-7, 2004

 83.    Iwasaki K, Zhang R, Zuckerman JH, Perhonen M, Levine BD.  Reduced baroreflex control of heart rate after bed rest is normalized by acute plasma volume restoration.  American Journal of Physiology:  Regulatory, Integrative and Comparative Physiology, 287 (5) R1256-62, 2004.

 84.    Arbab-Zadeh A, Dijk E, Prasad A, Fu Q, Torres P, Zhang R, Thoma JD, Palmer DM, Levine BD.  Effect of Aging and Physical Activity on Left Ventricular Compliance.  Circulation, 110 (13), 1799-1805, Sept. 28, 2004.

85.    Fu Q, Witkowski S, Levine BD.  Vasoconstrictor reserve and sympathetic neural control of orthostasis.  Circulation, 110:2931-2937, 2004.

86. Rivera J, Hillis LD, Levine BD. Reactivation of cardiac Chagas' disease in acquired immune deficency syndrome.  Am J Cardiol. 94(8): 1102-3, Oct 15, 2004.

87.    Fu Q, Zhang R, Witkowski S, Arbab-Zadeh A, Prasad A, Okazaki K, Levine BD.  Persistent sympathetic activation during chronic antihypertensive therapy:  A potential mechanism for long term morbidity?  Hypertension, 45:1-9, 2005.

88.  Ge RL, Stone JA, Levine BD, Babb TG. Exaggerated respiratory chemosensitivity and association with SaO2 level at 3568 m in obesity.  Respiratory Physiology & Neurobiology, 146, 1:47-54, 2005.

89. Okazaki K, Iwasaki K, Prasad A, Palmer D, Martini E, Fu Q, Arbab-Zadeh A, Zhang R, Levine BD. Dose-response relationship of endurance training for autonomic circulatory control in healthy seniors. Journal of Applied Physiology, 99:1041-1049, 2005.

90. Prasad A, Okazaki K, Arbab-Zadeh A, Dijk E, Fu Q, Thomas JD, Levine BD. Abnormalities of Doppler Measures of Diastolic Function in the Healthy Elderly are not Related to Alterations of Left Atrial Pressure, Circulation, 111:1499-1503, 2005.

91. Fu Q, Witkowski S, Okazaki K, Levine BD. Effects of Gender and Hypovolemia on Sympathetic Neural Responses to Orthostatic Stress. Am J Physiol Regul Integr Comp Physiol, 289, R109-R116, 2005.

92. Wilson TE, Zhang R, Levine BD, Crandall CG. Dynamic autoregulation of cutaneous circulation: differential control in glabrous versus nonglabrous skin. Am J. Physiol. Heart Circ. Physiol. 289:H385-H391, 2005.

93. Cui J., Arbab-Zadeh A, Prasad A, Durand S, Levine BD, Crandall CG. Effects of heat stress on thermoregulatory responses in congestive heart failure patients. Circulation. 112:2286-2292, Oct. 11, 2005.

94. LaMonte MJ, FitzGerald SJ, Church TS, Barlow CE, Radford NB, Levine BD, Pippin JJ, Gibbons LW, Blair SN, Nichaman MZ. Coronary Artery Calcium Score and Coronary Heart Disease Events in a Large Cohort of Asymptomatic Men and Women, Am J Epidemiol. 162(5):1-9, 2005.

95. Okazaki K, Fu Q, Martini ER, Shook R, Conner C, Zhang R, Crandall CG, Levine BD. Vasoconstriction during venous congestion: effects of the venoarteriolar response, myogenic reflexes and hemodynamics of changing perfusion pressure. Am J Physiol Regul Integr Comp Physiol. 289:R1354-R1359, 2005.

96. Cui J, Durand S, Levine BD, Crandall CG. Effect of skin surface cooling on central venous pressure during orthostatic challenge.  Am.J.Physiol.Heart.Circ.Physiol., 289(6):H2429-H2433, 2005.

97. Lian Y, Kubo K, Ge Ri-Li, Levine BD, Babb T.  The effect of exposure to normobaric hypoxia on the body weight in rats. J of Qinghai Medical College, 26:153-155, 2005.

99. Ge Ri-Li, Babb TG, Sivieri M, Resaland GK, Karlsen T, Stray-Gundersen J, Levine BD. Urine Acid-Base Compensation at Simulated Moderate Altitude. High Altitude Medicine & Biology. Vol. 7, Number 1, 64-71, 2006.

100. Mitsis GD, Zhang R, Levine BD, Marmarelis VZ. Cerebral Hemodynamics during Orthostatic Stress assessed by Nonlinear Modeling.  J. Appl.Physiol.,101(1):354-66, 2006.

101. Chung AK, Das SR, Leonard D, Peshock RP, Kazi F, Abdullah SM, Canham RM, Levine BD, Drazner MH. Women have a higher left ejection fraction than men independent of their smaller left ventricular volume: the Dallas Heart Study. Circulation, 113:1597-1604,2006.

102. Popovic ZB, Richards KE, Greenberg NL, Rovner A, Drinko J, Cheng Y, Penn MS, Fukamachi K, Mal N, Levine BD, Garcia MJ, Thomas JD.  Scaling of Diastolic Intraventricular Pressure Gradients is Related to Filling Time Duration. Am.J.Physiol.Heart.Circ.Physiology. Aug;291(2):H762-9,2006.

103. Shibata S, Zhang R, Hastings J, Fu Q, Okazaki K, Iwasaki K,  Levine BD. A cascade model of ventricular-arterial coupling in and arterial-cardiac baroreflex function for cardiovascular variability in humans.  AJP: Heart and Circulatory Physiology, Nov;291(5):H2142-51, 2006.

104.  Gore C, Rodriguez FA, Stray-Gundersen J, Truijens MJ, Townsend N, Levine BD.  Increased serum erythropoietin but not red cell production after 4 wk of intermittent hypobaric hypoxia (4000 – 5500m).  JAP, in press, 2006.

105. Fu Q, Shook R, Okazaki K, Hastings JL, Shibata S, Conner C, Palmer DM, Levine BD. Vasomotor Sympathetic neural control is maintained during sustained upright posture in humans. Journal of Physiology, 577.2:679-687, 2006.

106. LaMonte MJ, Fitzgerald SJ, Levine BD, Church TS, Kampert JB, Nichaman MZ, Gibbons LW, Blair SN. Coronary artery calcium, exercise tolerance, and CHD events in asymptomatic men. Atherosclerosis, 189(1), 157-62, Nov. 2006.

107. Lundby C, Calbet J, Sander M, van Hall G, Mazzeo RS, Stray-Gundersen J, Saltin B, Levine BD. Exercise Economy does not Change after Acclimatization to Moderate to very High Altitude. Scandinavian Journal of Medicine & Science in Sports, DOI:10.1111/j.1600-0838.2006.00530.x
 

108. Church T, Levine BD, McGuire D, LaMonte MJ, Fitzgerald SJ, Cheng YJ, Kimball TE, Blair SN, Gibbons LW, Nichaman MZ.  Coronary Artery Calcium Score, Risk Factors and Incident CHD Events.  Artherosclerosis, 190(1):224-31, Jan.2007.

109.  Hawkins M, Raven PB, Stray-Gundersen J, Snell PG, Levine BD.  Maximal oxygen uptake as a parametric measure of cardiorespiratory capacity.  Med.Sci.Sports. Exercise 39(1):103-7, 2007.

110. Iwasaki K, Levine BD, Zhang R, Zuckerman JH, Pawelczyk JA, Diedrich A, Ertl AC, Cox JF, Giller CA, Ray CA, Lane LD, Buckey JC, Baisch F, Eckberg DL, Robertson D, Biaggioni I, Blomqvist G. Human cerebral autoregulation before, during, and after spaceflight.  Journal of Physiology, 579.3 799-810, 2007.

111. Claassen JA, Zhang R, Fu Q, Witkowski S, Levine BD. Transcranial Doppler estimation of cerebral blood flow and cerebrovascular conductance during modified rebreathing.  J.Appl.Physiol 102:870-877,2007.

112. Zhang R, Witkowski S, Fu Q, Claassen J, Levine BD.  Cerebral hemodynamics after short and long-term reduction in blood pressure in mild and moderate hypertension.  Hypertension, 49(5):1149-55.2007.

113. Zhang R, Levine BD.  Autonomic ganglionic blockade does not prevent reduction in cerebral blood flow velocity during orthostasis in humans.  Stroke, April 38 (4):1238-44, 2007.

 114. Prasad A, Popovic ZP, Arbab-Zadeh A, Fu Q, Palmer DM, Dijk E, Garcia MJ, Thomas JD, Levine BD.  The effects of aging and physical activity on Doppler measures of diastolic function.  American Journal of Cardiology 99:1629-36, 2007.

 115. Fu Q, Townsend NE, Shiller SM, Martini ER, Okazaki K, Shibata S, Truijens MJ, Rodriguez FA, Gore CJ, Stray-Gundersen J, Levine BD.  Intermittent hypobaric hypoxia exposure does not cause sustained alterations in autonomic control of blood pressure in young athletes.  Journal of Applied Physiology 292:1977-84, 2007.

 116.  Low DA, Vu A, Brown M, Davis SL, Keller DM, Levine BD, Crandall CG.  Temporal thermometry fails to track body core temperature during heat stress. Med. Sci Sports Exerc:39:1029-35, 2007

117.  Dorfman TA, Levine BD, Tillery T, Peshock RM, Hastings JL, Schneider SM, Macias BR, Biolo G, Hargens AR.  Cardiac atrophy in women following bed rest.  J Appl Physiol:103-8-16, 2007.

 118. Jarvis SS, Levine BD, Prisk GK, Shykoff BE, Elliott AR, Rosow E, Blomqvist CG, Pawelczyk JA.  Simultaneous Determination of the Accuracy and Precision of Closed-Circuit Cardiac Output Rebreathing Techniques.  JAP, Sep; 103(3):867-74, 2007.

 119.  McGavock JM, Lingvay I, Zib I, Tillery T, Salas N, Unger R, Levine BD, Raskin P, Victor RG, Szcepaniak LS.  Cardiac Steatosis in Diabetes Mellitus:  A 1H-Magnetic Resonance Spectroscopy Study.  Circulation, 2007;116(10):1170 – 5, 2007.

 120. Rodriguez F, Truijens M, Townsend M, Stray-Gundersen J, Gore C, Levine BD.  Performance of runners and swimmers after four weeks of intermittent hypobaric hypoxic exposure plus sea level training.  J Appl Physiol, 103; 1523 – 35, 2007.

 

Selected Reviews and Book Chapters: (Total 43 published)

  1. Levine BD, The role of barometric pressure in high altitude illness. Wilderness Medicine 5(1):6-7, 1988.
  2. Levine BD, Roach RC, Houston CS. Work and training at altitude, In Hypoxia: Mountain Medicine, Sutton JR, Coates G, Houston CS, eds., Queen City Publishers Burlington, Vermont, p. 192-201, 1992.
  3. Levine BD, Friedman DB, et. al. Starting a cardiac rehabilitation program: theory and practice. Cardio 9:26-37, 1992.
  4. Levine BD, Stray-Gundersen J. A practical approach to altitude training: where to live and train for optimal performance enhancement. Int J Sports Med 13(S1):S209-S212, 1992.
  5. Levine BD. Regulation of central blood volume and cardiac filling in endurance athletes: the Frank-Starling mechanism as a determinant of orthostatic tolerance. Med Sci Sports Exercise 25:727-732, 1993.
  6. Grossfeld P, Friedman DB, Levine BD. Traumatic myocardial infarction during sports: a report of a case during competitive volleyball and a review of the literature. Med Sci Sports Exercise 25:901-903, 1993
  7. Levine BD, Mitchell JH. 'Ultra' coronary arteries: bigger and better? Circulation 87:1402-1404, 1993.
  8. Levine BD. By what physiological mechanism is dexamethasone beneficial in the prevention of acute mountain sickness. Journal of Wilderness Medicine 4(1):106-109, 1993.
  9. Blomqvist CG, Gaffney FA, Wright SJ, Buckey JC, Lane LD, Meny GM, Levine BD, Peshock RM, Stray-Gundersen J, Graham RM. Cardiovascular regulation at microgravity (AR-CARD3). In: Research Program of the German Spacelab Mission D-2. (Eds.) Sahm PR, Keller MH, Schiewe B. DLR Koln, Germany: Wissenschaftliche Projektfuhrung Spacelabmission D-2. Second edition, pp. 67-69, 1993.
  10. Levine BD, Schecter MG. Exercise at high altitude. In Sports Medicine Secrets. MB Mellion (ed). Philadelphia: Hanley & Belfus, Inc., p.90-95, 1994.
  11. Blomqvist CG, Buckey JC, Lane LD, Levine BD, Meny GM, Wright SJ, Gaffney FA, Watenpaugh DE, Baisch F. Mechanisms of post-flight orthostatic intolerance. D-2 Symposium, March 14-16, Norderncy, pp. 19-20, 1994.
  12. Levine BD, Stray-Gundersen J. The medical care of competitive athletes: the role of the physician and individual assumption of risk. Med Sci Sports Exercise 26:1190-1192, 1994.
  13. Thompson PD, Klocke F, Levine BD, Van Camp S. Acquired coronary artery disease task force, presented at 26th Bethesda Conference: Recommendations for Determining Eligibility for Competition in Athletes With Cardiovascular Abnormalities, Jour Am Col Card 24:845-899, 1994.
  14. Levine BD, Stray-Gundersen J. Exercise at high altitudes. In: Current Therapy in Sports Medicine. 3rd ed. JS Torg and RJ Shepard (eds). Missouri: Mosby-Year Book, Inc., p. 588-593, 1995.
  15. Levine BD. Training and exercise at high altitudes. In: Sport, Leisure, and Ergonomics. G Atkinson and T Reilly (eds). London: E & FN Spon, p. 74-92, 1995.
  16. Blomqvist CG, Levine BD, Lane LD, Buckey JC. Space medicine and physiology. In: Current Medicine. Atlas of Heart Diseases, Vol 6. E Braunwald (ed). Philadelphia: Mosby, Inc., Chapter 10, p. 10.20-10.21, 1996
  17. Levine BD. Critical discussion of research issues in mechanisms of cardiovascular adaptation to actual and simulated µG. Med Sci Sports Exercise 28(10):S90-S93, 1996.
  18. Stray-Gundersen J, and Levine BD. "Living high and training low" can improve sea level performance in endurance athletes. British J. of Sports Med, June 1999, Vol 33, No. 3, p 150-151, 1999.
  19. O’Connor FG, Oriscello RG, Levine BD. Exercise-Related Syncope in the Young Athlete: Reassurance, Restriction, American Family Physician, 60:2001-2008, 1999.
  20. Chapman RF, Levine BD. The effects of hypo and hyperbaria on performance. Textbook of Sports MedicineExercise: Basic and Applied Science, William E Garrett, Jr., and Donald Kirkendall, ed., Lippincott Williams & Wilkins, Philadelphia, Chapter 30, p447-458, 2000.
  21. Levine BD. Mountain medicine and the autonomic nervous system, Chapter 9. In: The Autonomic Nervous System, Part II. Dysfunctions. Handbook of Clinical Neurology Vol. 75 (Rev. Ser. 31), O. Appenzeller (Ed.), 2000.
  22. Levine BD, Friedman DB, Blomqvist CG, Mitchell JH. Preventive Cardiology: Exercise. In: Cardiovascular Medicine, Willerson JT and Cohns JN (eds), New York: Churchill Livingston, p. 1872-1883, 1995, 2nd edition 2000.
  23. Levine BD, Zuckerman JH, Cole C. Medical complications of Exercise. In: American College of Sports Medicine’s Resource Manual: Guidelines for Exercise Testing and Prescription, third edition, JL Roitman, ed, Baltimore: Williams and Wilkins, (1998), p 501-510, fourth edition, 2001.
  24. Levine BD. Exercise physiology for the clinician. Textbook of Exercise and Sports Cardiology. Paul D.Thompson, ed., McGraw Hill,. Chapter 1, p3-29, 2001.
  25. Levine BD, Stray-Gundersen J. High-altitude training and competition. In: The Team Physician’s Handbook, 2nd ed. MB Mellion, WM Walsh, GL Shelton (eds). Philadelphia: Hanley & Belfus, Inc., 3rd edition, 159-165, 2002
  26. Wolfel EE, Levine BD. The Cardiovascular System at High Altitude: Heart and systemic circulation. In: High Altitude. TF Hornbein and RB Schoene (eds), Marcel Dekker, Chapter 9, p. 235-292, August, 2001.
  27. Levine BD, and Stray-Gundersen J. The effects of altitude training are mediated primarily by acclimatization, rather than by hypoxic exercise. Hypoxia: From Genes to the Bedside, Adv Exp Biol Med (502). R.C. Roach, P.D. Wagner and P.H. Hackett. New York, Kluwer/Plenum Academic: 75-88, 2001.
  28. Arbab-Zadeh A, Crandall C, Levine BD. Thermoregulation in Patients with Cardiac Disease. Editorial - J of Cardiopulmonary Rehabilitation, 22:385-386, 2002.
  29. Levine BD. Intermittent Hypoxic Training: Fact and Fancy. High Altitude Medicine & Biology, 3:177-194, 2002.
  30. Levine BD, Pawelczyk JA, Zuckerman JH, Zhang R, Iwasaki K, Blomqvist CG. Neural Control of the Cardiovascular System in Space, NASA, 1-11,  The Neurolab Spacelab Mission: Neuroscience Research in Space: Results from the STS-90, Neurolab Spacelab Mission, Jay C Buckey and Jerry L Homick (eds) Lyndon B. Johnson Space Center, 175-185, January, 2003.
  31. Fu Q, Levine BD. Cardiovascular Response to Exercise in Women. Medicine & Science in Sports & Exercise, V37, No. 8, 1433 – 1435, 2005.
  32. Levine BD, Thompson PD. Marathon Maladies. New England Journal of Medicine, 352;15:1516-1518, April 14, 2005.
  33. King ML, Williams MA, Fletcher GF, Gordon NF, Gulanick M, King CN, Leon AS, Levine BD, Costa F, Wenger NK. Medical Director Responsibilities for Outpatient Cardiac Rehabilitations/Secondary Prevention Programs. A Scientific Statement from the American Heart Association/American Association for Cardiovascular and Pulmonary Rehabilitation. Circulation, 112:3354-3360, 2005.
  34. Levine BD, Stray-Gundersen J. Point: Positive effects of intermittent hypoxia (live highli>
  35. Thompson PD, Balady GJ, Chaitman BR, Clark LT, Levine BD, Myerburg RJ. Bethesda Conference 36; Task Force 6: coronary artery disease.
    J Am Coll Cardiol. Apr 19;45(8):1348-53, 2005.
  36. Levine BD, Pelliccia A, Thompson PD, Douglas PS, Fu Q, Di Paolo F, Kiernan F, Zasadil M. The cardiovascular evaluation of women athletes. Medicine & Science in Sports & Exercise 37: 1431-1432, 2005.
  37. Fu Q, Levine BD. Cardiovascular response to exercise in women. Medicine & Science in Sports & Exercise, 37:1433-1435, 2005.
  38. Fu Q, Levine BD. Hypertension and Antihypertensive Therapy in Elderly Women: How much do we really know? Hypertension, 47:323-324, 2006.

  39. Levine BD, Stray-Gundersen J. Dose-Response Of Altitude Training: How Much Altitude Is Enough? Advances Exp Biol Med 588:233-47, 2006

  40. Levine BD.  The Grinch syndrome: a new name for orthostatic hypotension and syncope. In: 2006 ACSM Annual Meeting Named Lectures [DVD]. Monterey, CA: Healthy Learning. ©American College of Sports Medicine, 2006.

  41. Levine BD. Should “artificial” high altitude environments be considered doping? Scandinavian J of Med Sci Sports 16(5): 297-301, 2006.

  42. Thompson PD, Levine BD. Protecting Athletes from Sudden Cardiac Death.  JAMA, Oct. 4;296(13):1648-50, 2006.

  43. Levine BD, et. al.  The ACCF/AHA Scientific Statement on Syncope – A document in need of thoughtful revision. Editorial in  Clin Auton Res, in press, 2006.

Ongoing Research Support
  1. Project #PR01101

Shigeki Shibata (PI)

12/1/2006 - 11/30/2008

NASA - NSBRI

"Impacts of bedrest, exercise, and aging on dynamic ventricular-arterial coupling"

The global objectives of this proposal are to assess the effects of aging and exposure to microgravity on ventricular-arterial stiffening, and to explore the optimal physical activity to prevent these ventricular-arterial stiffness by using new concept of “dynamic ventricular-arterial coupling” combined with classical evaluation for static ventricular-arterial stiffness.

Role: Sponsor

  1. Grant # 5 R01 AG17479-05 (competitive renewal) 

Levine (PI) 

9/5/2006 - 6/30/2011

NIH  

"Aging, Fitness, & Failure: Mechanisms of Diastolic Dysfunction"

The global object of this award is to determine the precise abnormalities of diastolic function associated with normal, healthy againg and compare these changes with those associated with congestive heart failure due to primarily to diastolic dysfunction.

Role:  PI             

  1. Experiment #0377

Levine (PI)

1/10/04 - 1/09/2009

NASA - HEDS

"Cardiac Atrophy and Diastolic Dysfunction During and After Long Duration Spaceflight: Functional Consequences for Orthostatic Intolerance and Risk of Cardiac Arrhythmias"

The global objective of this proposal is to quantify the extent and time course of cardiac atrophy and identify its mechanisms. The functional consequences of this atrophy also will be determined for cardiac filling dynamics, orthostatic tolerance, and arrhythmia susceptibility both in space on the International Space Station, and following return to earth.

Role:  PI

4.      Grant #R01 HL61388 

Crandall (PI)

1/01/04 – 12/31/08 (renewal)

NIH - Heart, Lung and Blood

"Heat Stress and Circulatory Control"

The purpose of this grant is to perform work to identify non-baroreflex mechanisms that may be responsible for reducing orthostatic tolerance during heat stress in humans.

Role: Co-Investigator

5.      1 K23 HL075283-01 

Fu (PI)

4/1/04 - 12/31/09

National Heart Lung and Blood Institute

"Gender & orthostatic intolerance: mechanisms and therapy"

The purpose of this study is to perform work to know whether gender-specific factors such as the menstrual cycle or physical factors influencing cardiac size and function are among the determinants for orthostatic intolerance in young women, and whether exercise training can be considered an effective non-pharmacologic measure for patients to improve their orthostatic tolerance.

Role:  Sponsor    

6.      NNH047ZUU003N

Levine (PI)

6/1/05 – 5/31/09

NASA-NSBRI

“The Multisystem Effect of Exercise Training/Nutritional Support During Prolonged Bed Rest Deconditioning:  An Integrative Approach to Countermeasure Development for the Heart, Lungs, Muscles and Bones”

The global objective of this proposal is to test an integrated countermeasure that will be effective against cardiovascular deconditioning, skeletal muscle atrophy, and bone demineralization, and that ultimately can be applied practically aboard the International Space Station or a mission to Mars. 

Role:  PI

7.     R01 AR050597

Haller (PI)

9/05/2006 - 8/31/2011

NIH

"Exercise Adaptations in mitochondrial myopathy"

Long term objective, to determine the safety and efficacy of endurance exercise trainng as therapy and the potentially adverse effects of habitual physical inactivity in patients with skeletal muscle mitochondrial defects.

Role: (Co-I)

8.      CA 00401

Levine (TL)

NASA-NSBRI

Team lead role

9.       Thoratec

Levine(PI)

9/1/2007 - 6/30/2008

Various investigator initiated protocols

Completed Research Support

1.      Grant # NAS 96-OLMSA-01B 

Levine (PI) 

10/01/98 – 09/30/01

NASA   

"The role of cardiac mechanics in blood pressure regulation during orthostatic stress: 

The effect of duration of exposure to simulated microgravity" The major goal of this project is to investigate the mechanism by which changes in cardiac structure (mass) and function (pressure-volume relationships) during short term (2 weeks) exposure to simulated microgravity affect the regulation of blood pressure during orthostatic stress, and to determine the efficacy of specific countermeasures including exercise training and volume infusion.    

Role:  PI        

2.      Grant # 2000057

 Levine (PI) 

7/1/2000 - 6/30/2003

Doris Duke Charitable Foundation  

"Heat Intolerance in Elderly Patients with CHF"

The purpose of this grant is to identify the mechanisms of heat intolerance in patients with heart failure (CHF).

Role:  PI

3.      Grant # R01 HL61388 

Crandall (PI) 

1/01/99 – 12/31/03

NIH – Heart, Lung, and Blood Institute

"Hyperthermia Effects on Human Baroreflex Function"

It is widely recognized that when in a hyperthermic state, individuals are more prone to fainting. Less understood is whether this thermal condition reduces the effectiveness of the baroreceptors to regulate blood pressure. Thus, the primary purpose of this grant is to assess the effects of hyperthermia on baroreceptor regulation of blood pressure in humans. 

Role: Co-Investigator

4.      Grant # 00600244 

Zhang (PI)

07/01/00 - 06/30/03  

American Heart Association - Texas Affiliate  

"Dynamic Cerebral Autoregulation in Hypertension"  

The main objective of this project is to gain new knowledge regarding the effects of hypertension and antihypertensive therapy on cerebral circulation. This will be particularly significant in understanding the role that cerebral autoregulation plays in stroke-prone hypertensive patients.  

Role: Co-Investigator

5.      Grant # 02250174Y 

Fu (PI) 

7/1/2002 - 6/30/2004

American Heart Association - Texas Affiliate Fellowship Award  

"Vasoconstrictor Reserve: A Mechanism for Individual Variability in Orthostatic Intolerance?"

The purpose of this research is to perform work to test the hypotheses that each human individual has a finite range of vasoconstrictor reserve that can be mediated by adrenergic activity, and a limited vasoconstrictor reserve is related to orthostatic intolerance both under normovolemia and hypovolemia conditions.

Role: Sponsor

6.      Grant # 0225036Y 

Cui (PI) 

7/1/2002 - 6/30/2004

American Heart Association 

"Mechanisms of Impaired Thermoregulation in Patients with Congestive Heart Failure"

The purpose of this research is to perform work to identify mechanisms of decrease in heat intolerance in patients with congestive heart failure (CHF), the function of pre- and post-synpatic regulation of skin blood flow and sweating will be tested in individuals with CHF. There are strong direct and indirect evidence to support the hypothesis that the thermoregulation is impaired in patients with congestive heart failure (CHF). During a heat stress patients with CHF may not perfuse the skin adequately to appropriately thermoregulate, leading to grave risk for heat injury.

Role: Consultant

7.      Grant # T-7332W

Levine (PI)

1/2/03 - 12/31/2003

NASA - NRA 99-HEDS-03

“Cardiac Atrophy and Diastolic Dysfunction During and After Long Duration Spaceflight: Functional Consequences for Orthostatic Intolerance and Risk of Cardiac Arrhythmias”

The purpose of this "T Award" was to complete the definition phase and obtain final approval for development and implementation of flight experiment #0377.

Role:  PI

8.      Grant #N/A

Levine (PI)

3/1/2003 - 12/31/2003

USOC

"Sea-level Performance of Runners and Swimmers after short-term, intermittent hypobaric hypoxia at rest (5,500 m)"

The purpose of this grant is to perform work to investigate the effects of intermittent exposure to short-term hypobaric hypoxia combined with sea-level training on hematological, biochemical, and performance parameters in well-trained runners and swimmers.

Role:  PI

9.  R01 HL67422-01A1 

Crandall (PI) 

1/1/2002 - 12/31/2005 (no cost extension to12/31/2006)

NIH- PA-00-088 – R01  

"Mechanisms of Skin Cooling to Improve Orthostatic Tolerance" 

The purpose of this grant is to identify the mechanisms by which skin surface cooling improves orthostatic tolerance.      

Role: Co-Investigator

10.  Grant # NA

Hastings (PI)

7/01/05 – 6/30/07

American Heart Association – TX Affiliate – Fellowship

“Rowing Ergometry as a Novel Countermeasure to Cardiac Deconditioning Due to Prolonged Bedrest”

The purpose of this grant is to perform work to evaluate an optimized exercise program consisting of rowing ergometry and resistance exercise as a prevention measure of cardiac deconditioning and atrophy in prolonged bedrest.

Role:  Sponsor

 
 

 

rev. 1/2008

Top of Page