Dr. Tony G. Babb:

Up Dr. Babb Dr. Crandall Dr. Haller Dr. Qi Fu Dr. Levine Dr. Martin Dr. Stone Dr. Zhang                       

BIOGRAPHICAL SKETCH

Tony G. Babb, Ph.D.

Assistant Professor
INSTITUTION AND LOCATION

DEGREE

 YEAR(s) FIELD OF STUDY
Western Kentucky University, Bowling Green, KY

B.S.

1976

Biology

University of Illinois, Urbana, IL

M.S.

1981

Exercise Physiology
Pennsylvania State University, University Park, PA

Ph.D.

1986

Exercise Physiology

PROFESSIONAL EXPERIENCE:

1/87-5/89 Research Fellow, Thoracic Diseases Research Unit, Mayo Graduate School of Medicine, Mayo Clinic, Rochester, MN

5/89-6/90 Research Associate, Pulmonary Section, Department of Medicine, Baylor College of Medicine, Houston, Texas

7/90-6/91 Research Instructor, Pulmonary Section, Department of Medicine, Baylor College of Medicine, Houston, Texas

7/91-6/92 Research Assistant Professor, Pulmonary Section, Department of Medicine, Baylor College of Medicine, Houston, Texas

7/92-Present Assistant Professor, Department of Internal Medicine/Pulmonary and Critical Care Medicine, The University of Texas Southwestern Medical Center/Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, Texas

2/2005-Present Associate Professor, Department of Internal Medicine/Pulmonary and Critical Care Medicine,  The University of Texas Southwestern Medical Center/Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, Texas

 

SOCIETIES AND HONORS:

NIH Institutional National Research Service Award

First Independent Research Support and Transition Award

Fellow, American College of Sports Medicine

Member, American Physiological Society

Member, American Thoracic Society

RSF Program Committee, American Thoracic Society, 1998-Present

American College of Sports Medicine Respiratory Physiology Area Representative, 1996-2000

Member, Editorial Board of the Journal of Applied Physiology, 1996-1999

Member of the Board of Directors of the Texas Chapter of the American College of Sports Medicine, 1997-1999

ALA Career Investigator Award, 1999

Holder of the Effie and Wofford Cain Chair in Cardiopulmonary Research

SELECTED PUBLICATIONS:
  1. Babb TG, Turner N, Saupe K, Pawelczyk J. Physical performance during combinations of hypercapnic, resistive, and hot air breathing. Am Ind Hyg Assoc J, 50:105-111, 1989.
  2. Babb TG, Buskirk ER, Hodgson JL. Exercise end-expiratory lung volumes in lean and moderately obese women. Int J Obesity, 13:11-19, 1989.
  3. Babb TG, Viggiano R, Hurley B, Staats B, Rodarte Jr. Effect of mild to moderate airflow limitation on exercise capacity. J Appl Physiol, 70:223-230, 1991.
  4. Babb TG and Rodarte JR. Lung volumes during low-intensity steady-state cycling. J Appl Physiol, 70:934-937, 1991.
  5. Babb TG, Korzick D, Meador M, Hodgson JL, Buskirk ER. Ventilatory response of moderately obese women to incremental exercise. Int J Obesity, 15:59-65, 1991.
  6. Beck KC, Babb TG, Staats BA, Hyatt RE. Dynamics of breathing in exercise. In "Exercise: Pulmonary Physiology and Pathophysiology." Eds: BJ Whipp & K Wasserman, Marcel Dekker, Inc., New York, 1991.
  7. Babb TG and Rodarte JR. Exercise capacity and breathing mechanics in patients with airflow limitation. Med Sci Sports Exerc, 24:967-974, 1992.
  8. Pellegrino R, Brusasco V, Rodarte JR, and Babb TG. Expiratory flow limitation and regulation of end-expiratory lung volume during exercise. J Appl Physiol, 74:2552-2558, 1993.
  9. Babb TG and Rodarte JR. Estimation of ventilatory capacity during submaximal exercise. J Appl Physiol, 74:2016-2022, 1993.
  10. Babb TG. Ventilatory response to exercise in subjects breathing inspired CO2 or HeO2. J Appl Physiol 82:746-754, 1997.
  11. Williams JS and Babb TG. Differences between estimates and measured PaCO2 during rest and exercise in older subjects. J Appl Physiol 83:312-316, 1997.
  12. Babb TG, Long KA, and Rodarte JR. The relationship between maximal expiratory flow and increases of maximal exercise capacity with exercise training. Am J Resp Crit Care Med 156:116-121, 1997.
  13. Babb TG. Ventilation and respiratory mechanics during exercise in younger subjects breathing CO2 or HeO2. Resp Physiol 109:15-28, 1997.
  14. Babb TG. Mechanical ventilatory constraints in aging, lung disease, and obesity: perspective and brief review. Clinical Supplement in Pulmonary Medicine Med Sci Sport Exerc 31:S12-S22, 1999.
  15. DeLorey DS and Babb TG. Progressive mechanical ventilatory constraints with aging. Am J Respir Crit Care Med, 160:169-177, 1999.
  16. O'Kroy JA, JM Lawler, J Stone, and TG Babb. Airflow limitation and control of end-expiratory lung volume during exercise. Respir Physiol, 119(1):57-68, 2000.
  17. Babb TG, and Rodarte, JR. Mechanism of reduced maximal expiratory flow with aging. J Appl Physiol, 89:505-511, 2000.
  18. Babb TG, Breathing HeO2 increases ventilation but does not decrease the work of breathing during exercise. Am J Respir Crit Care Med, 163:1128-1134, 2001.
  19. Babb TG, DS DeLorey, BL Wyrick, and PP Gardner. Mild obesity does not limit change in end-expiratory lung volume during cycling in young women. J Appl Physiol., 92:2483-2490, 2002.
  20. Babb TG and DeLorey DS. Hyperventilation with He-O2 breathing is not decreased by superimposed external resistance. Respir Physiol & Neurobiology, 133:139-151, 2002
  21. Babb TG, DeLorey DS, and Wyrick BL. Ventilatory response to exercise in aged runners breathing He-O2 or inspired CO2. J Appl Physiol, 94:685-693, 2003.
  22. Ge RL, Chase PJ, Witkowski S, Wyrick BL, Stone JA, Levine BD, Babb TG. Obesity: Associations with Acute Mountain Sickness, Annals of Internal Medicine, 139:4:253-258, 2003.

  23. Ge RL, Stone JA, Levine BD, Babb TG.  Exaggerated respiratory chemosensitivity and association with SaO2 level at 3568 m in obesity.  Respiratory. Physiology & Neurobiology, 146, 1: 47-54, 2005.

  24. DeLorey DS, Wyrick BL, and Babb TG. Mild-to-moderate obesity: implications for respiratory mechanics at rest and during exercise in young men. INT J. Obesity, 1-9, 2005.

  25. Babb TG, BL Wyrick, DS DeLorey, PJ Chase, P Weatherall, and MY Feng.  Rib Cage and Abdominal Fat:  Effects on End Expiratory Lung Volume in Mildly Obese Men and Women.  In Revision, International Journal of Obesity, 2005.

  26. Babb TG. Maximal expiratory flow and the ventilatory response to exercise. Journal of Qinghai Medical College, 26:73-88,2005.

  27.  Lian Y, Kubo K, Ge Ri-Li, Levine B, Babb T. The effect of exposure to normobaric hypoxia on the body weight in rats. J of Qinghai Medical College, 26: 153-155, 2005.

  28. Babb TG. Estimation of mechanical ventilatory limitation. Journal of Qinghai Medical College, 26: 145-152, 2005.

  29.  Mitchell GS and Babb TG. Invited Review: Layers of exercise hyperpnea: Modulation and plasticity. Resp Physiol & Neurobiology, 151:251-266, 2006.

  30. Ge Ri-Li, Babb TG, Sivieri M, Resaland GK, Stray-Gundersen J, Levine BD, Karlsen T. Study on Urine Acid-Base Compensation at Simulated Moderate Altitude. High Altitude Medicine & Biology. 7: 64-71, 2006.

  31. Sharafkhaneh A, Babb TG, Officer TM, Hanania NA, Sharafkhaneh H, Boriek AM. The confounding effect of thoracic gas compression on measurement of acute bronchodilator response.  Am J Respir Crit Care Med Vol 175. pp 330–335, 2007.

 

GRANT SUPPORT:

Ongoing Research Support

1) Grant # NNHO47ZUU003N

 Levine (PI)

6/1/2005 - 5/31/2009

NASA "The Multisystem Effect of Exercise Training/Nutritional Support During Prolonged Bed Rest Deconditioning:  An Integrative Approach to Countermeasure Development for the Heart, Lungs,Muscles and Bones"

The global objective of this proposal is to test an integrated countermeasure that will be effective against cardiovascular deconditioning, skeletal muscle atrophy, and bone demineralization, and that ultimately can be applied practically aboard the International Space Station or a mission to Mars.

Role:  Co-Investigator

2) MannKind Corporation

Babb (Co-I)

10/25/2005 - 10/24/2009

Pulmonary Function

Completed Research Support

1)  Grant # R01 AG17479-01A2

 Levine (PI) 

9/15/2001 – 9/14/2005 

NIH  "Aging, Fitness, & Failure: Mechanisms of Diastolic Dysfunction" 

The global object of this proposal is to determine the precise abnormalities of diastolic function associated with normal, healthy aging and compare these changes with those associated with congestive heart failure due to primarily to diastolic dysfunction.

Role: Co-Investigator                                                                                       

2)  Clinical Trial #205.252 

Babb (PI) 

09/2002 - 09/2003 Boehringer Ingelheim Pharmaceuticals Inc.

The objective of this trial  is to compare the bronchodilator efficacy of two doses (5 mg and10 mg) of tiotranpium inhalation solution delivered by inhaler once daily to placebo and ipratropium bromide aerosol (MDI) four times daily in patients with chronic obstructive pulmonary disease, (COPD).

3)  Grant # 0355045Y

 Babb (PI) 

7/01/2003 – 06/30/2005 

American Heart Association - TX Affiliate - Grant in Aid  "Shortness of Breath during Exertion in Obesity:  Cardiovascular Deconditioning or Respiratory Limitation" 

The objective of this study is to determine if exertional dyspnea in otherwise healthy obese adults is due to cardiovascular deconditioning or due to obesity-related respiratory limitations, specifically a prohibitive increase in the energy cost of breathing (i.e., increased oxygen cost of breathing).

Role: P.I.        

4)  Grant # 0050274N 

Johnson (PI) 

1/1/2000 - 12/31/2001American Heart Association

"Relative Rates of Pulmonary and Cardiovascular Aging"

The objective of this study is to determine the relative rates of aging of the cardiovascular and respiratory systems in a group of normal subjects who were extensively studied 30 years ago after bed rest and after 8 weeks of endurance training.

Role: Co-PI

5)  Clinical Trial #205.223 

Babb (PI) 

4/1/2001 - 12/31/2002 Boehringer Ingelheim

The objective of this trial is to investigate whether long acting inhalation bronchodilator therapy can increase the duration of constant work rate exercise by decreasing static and dynamic lung hyperinflation in patients with moderate to severe COPD.

6)  Grant # C1-015-N 

Babb (PI) 

7/1/1999 - 12/30/2002 American Lung Association - Career Investigator Award

"Mechanical Effects of Obesity during Exercise"

The purpose of this study is to determine the mechanical effects of mild-to-moderate obesity on pulmonary function at rest and respiratory mechanics during exercise.

 

 

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