Qi Fu, PhD, MD

Scientist Instructor

PROFESSIONAL EXPERIENCE: 1989 – 1995 Resident, Physician, Teaching Assistant (full-time)
Department of Neurology, The Second Affiliated Hospital of Suzhou
University, China
Department Head: Shiyao Bao, M.D.
1995 – 1997 Physician-in-Charge, Neurologist, Lecturer (full time)
Department of Neurology, The Second Affiliated Hospital of Suzhou
University, China
Department Head: Shiyao Bao, M.D.
2000 – 2001 Research Assistant (full-time)
Department of Autonomic Neuroscience
Research Institute of Environmental Medicine, Nagoya University, Japan
Department Head: Tadaaki Mano, M.D., Ph.D., Director
2001 – 2001 Research Resident (full-time)
Department of Autonomic Neuroscience
Research Institute of Environmental Medicine, Nagoya University, Japan
Supervisor: Satoshi Iwase, M.D., Ph.D.
2001 – 2004 Research Associate Fellow (full-time)
Institute for Exercise & Environmental Medicine, Dallas, Texas
Supervisor: Benjamin D. Levine, M.D., Director
2004 - Instructor
Cardiology Division, Internal Medicine
The University of Texas Southwestern Medical Center at Dallas
Dallas, TX, USA
9/2006 – Present - Assistant Professor
Cardiology Division Internal Medicine
The University of Texas Southwestern Medical Center at Dallas

Honors and Awards:

1984 – 1988   Studentship of Suzhou University, School of Medicine, China
1989               The Best Medical Student Award of Suzhou University, School of Medicine,                        China
1993               Chou's Medical Research Award of Wen-Xuan Chou's Foundation
1994               XU's Medical Research Award of Mrs Xiang Xu's Foundation
1995               The Outstanding Postgraduate Award of Suzhou University, School of                        Medicine
1997 – 2001   The Japanese Government (Monbushou) Scholarship
2001               The Japanese Foundation for Aging and Health
2002 – 2004   The American Heart Association (AHA) Grant - Texas Affiliate Fellowship                        Award
2004               David H. P. Streeten Travel Fellowship Award
2004 – 2009   National Institutes of Health (National Heart, Lung, and Blood Institute):
                       The Mentored Patient-Oriented Research Career Development Award

Professional Societies

1992 – 1997          Chinese Society of Neuroscience
1997 – 2001          Japanese Society of Space and Environmental Medicine
1997 – 2001          Japanese Society of Autonomic Neuroscience
2001 – Present      American Society of American College of Sports Medicine
 

1. Prasad A, Popovic ZP, Arbab-Zadeh A, Fu Q, Palmer DM, Dijk E, Garcia MJ, Thomas JD, and Levine BD. The effects of aging and physical activity on Doppler measures of diastolic funcion.  American Journal of Cardiology 99(12):1629-1636, 2007.
2. Zhang R, Witowski S, Fu Q, Claassen JA, and Levine BD. Cerebral hemodynamics after short and long-term reduction in blood pressure in mild and moderate hypertension.  Hypertension 49 (5): 1149-1155, 2007.
3. Fu Q, Townsend NE, Shiller SM, Martini ER, Okazaki K, Shibata S, Truijens MJ, Rodrigues FA, Gore CJ, Stray-Gundersen J, and Levine BD.  Intermittent hypobaric hypoxia exposure does not cause sustained alterations in autonomic control of blood pressure in young athletes. American Journal of Physiology Regulator, Integrated, and Comparative Physiology 292(5):R1977-R1984, 2007.
4. Claassen JA, Zhang R, Fu Q, Witkowski S, and Levine BD. Transcranial Doppler estimation of cerebral blood flow and cerebrovascular conductance during modified rebreathing.  Journal of Applied Physiology 102(3):870-877
5. Fu Q, Shook PR, Okazaki K, Hasting JL, Shibata S, Conner CL, Palmer MD, Jacob G, and Levine BD.  Vasomotor sympathetic neural control is maintained during sustained upright posture in humans.  Journal of Physiology 577(2):679-687, 2006.
6. Fu Q and Levine BD. Hypertension and antihypertensive therapy in elderly women: How much do we really know? (editorial commentary). Hypertension 47: 323-324,2006.
7.  Shibata S, Zhang R, Hastings J, Fu Q, Okazaki K, Iwasaki K, and Levine BD. A cascade model of ventricular-arterial coupling and arterial-cardiac baroreflex function for cardiovascular variability in humans. Am J Physiol Heart Circ Physiol 2006 Jun 9; [Epub ahead of print].
8.  Claassen J, Zhang R, Fu Q, Witkowski S, and Levine BD. Assessment of cerebral vasomotor reactivity during transient changes in CO2. Stroke 2006 (under review).
9. Levine BD, Pelliccia A, Thompson PD, Douglas PS, Fu Qi, Di Paolo F, Kiernan F, Zasadil M. The cardiovascular evaluation of women athletes. Medicine & Science in Sports & Exercise 37: 1431-1432, 2005.
10. Fu Q and Levine BD. Cardiovascular response to exercise in women. Medicine & Science in Sports & Exercise 37: 1433-1435, 2005.
11. Okazaki K, Fu Q, Martini ER, Shook R, Conner C, Zhang R, Crandall CG, and Levine BD. Vasoconstriction during venous congestion: effect of venoarteriolar response, myogenic reflexes, and hemodynamics of changing perfusion pressure. American Journal of Physiology Regulatory, Integrative and Comparative Physiology 289: R1354-R1359, 2005.
12. Okazaki K, Iwasaki K, Prasad A, Palmer MD, Martini ER, Fu Q, Arbab-Zadeh A, Zhang R, and Levine BD. Dose-response relationship of endurance training for autonomic circulatory control in healthy seniors. Journal of Applied Physiology 99: 1041-1049, 2005.
13. Prasad A, Okazaki K, Arbab-Zadeh A, Dijk E, Fu Q, Thomas JD, and Levine BD. Abnormalities of Doppler measures of diastolic function in the healthy elderly are not related to alterations of left atrial pressure. Circulation 111: 1499-1503, 2005.
14. Fu Q, Zhang R, Witkowski S,  Arbab-Zadeh A, Prasad A, Okazaki K, and Levine BD. Persistent sympathetic activation during chronic antihypertensive therapy: A potential mechanism for long term morbidity? Hypertension 45: 513-521, 2005.
15. Fu Q, Witkowski S, Okazaki K, and Levine BD. Effects of sex and hypovolemia on sympathetic neural responses to orthostatic stress. American Journal of Physiology Regulatory, Integrative and Comparative Physiology 289: R109-R116, 2005.
16. Prasad A, Popovic ZP, Arbab-Zadeh A, Fu Q, Palmer MD, Dijk E, Garcia MJ, Thomas JD, and Levine BD. The effects of aging and physical activity on left ventricular relaxation. Circulation 2005 (in revision).
17. Fu Q, Shook R, Okazaki K, Shibata S, Conner C, Palmer MD,  Jacob G, and Levine BD. Sympathetic baroreflex function and long-term control of arterial pressure during orthostatic stress in humans. Journal of Physiology 2006 (in press).
18. Fu Q, Shiller SM, Townsend NE, Martini ER, Okazaki K, Truijens MJ, Rodriguez F, Gore CJ, Stray-Gundersen J, and Levine BD. Intermittent hypobaric hypoxia exposure does not alter autonomic function in young athletes. Am J Physiol Regr Inter Comp Physiol 2006 (under review).
19. Fu Q, Witkowski S, and Levine BD. Vasoconstrictor reserve and sympathetic neural control of orthostasis. Circulation 110: 2931-2937, 2004.
20. Arbab-Zadeh A, Dijk E, Ochoa-Torres P, Fu Q, Zhang R, Thomas JD, Palmer D, and Levine BD. Effect of aging and physical activity on left ventricular compliance. Circulation 110: 1799-1805, 2004.
21. Fu Q,  Arbab-Zadeh A, Perhonen MA, Zhang R, Zuckerman JH, and Levine BD. Hemodynamics of orthostatic intolerance: Implications for gender difference. American Journal of Physiology Heart and Circulatory Physiology 286: H449-H457, 2004.
22. Michikami D, Kamiya A, Fu Q, Iwase S, Mano T, and Sunagawa K. Attenuated thermoregulatory sweating and cutaneous vasodilation after 14-day bed rest in humans. Journal of Applied Physiology 96: 107-114, 2004.
23. Qiu Y, Fu Q, Wang X, Tran TD,  Inui K, Iwase S, and Kakigi R. Microneurographic study of C fiber discharges induced by CO2 laser stimulation in humans. Neuroscience Letter 353: 25-28, 2003.
24. Kamiya A, Michikami D, Fu Q, Iwase S, Hayano J, Kawada T, Mano T, and Sunagawa K. Pathophysiology of orthostatic hypotension after bed rest: Paradoxical sympathetic withdrawal. American Journal of Physiology Heart and Circulatory Physiology 285: H1158-H1167, 2003.
25. Levine BD, Pawelczyk JA, Zuckerman JH, Zhang R, Fu Q, Iwasaki K, Ray C, and  Blomqvist CG. Neural control of the cardiovascular system in space. The Neurolab Spacelab Mission: Neuroscience Research in Space NASA 175-185, 2003.
26. Iwase S, Fu Q, Narita K, Morimoto E, Takada H, and Mano T. Effects of graded load of artificial gravity on cardiovascular functions in humans. Environmental Medicine 46: 29-32, 2002.
27. Fu Q, Levine BD, Pawelczyk JA, Ertl AC, Diedrich A, Cox JF, Zuckerman JF, Ray CA, Smith ML, Iwase S, Saito M, Sugiyama Y, Mano T, Zhang R, Iwasaki K, Lane LD, Buckey JC, Jr, Cooke WH, Robertson RM, Baisch FJ, Blomqvist CG, Eckberg DL, Robertson D, and Biaggioni I. Cardiovascular and sympathetic neural responses to handgrip and cold pressor stimuli in humans before, during and after spaceflight. Journal of Physiology  544.2: 653-664, 2002.
28. Fu Q, Vinogradova OL, Kamiya A, Michikami D, Cui J, Niimi Y, Iwase S, and Mano T. Effects of simulated microgravity on leg venous compliance in orthostatic intolerance. Aviakosm Ekology Med 36: 46-50, 2002.
29. Michikami S, Kamiya A, Fu Q, Niimi Y, Iwase S, Mano T, Suzumura A. Forearm elevation augments sympathetic activation during handgrip exercise in humans. Clinical Science (Lond) 103: 295-301, 2002.
30. Fu Q, Iwase S, Niimi Y, Kamiya A, Michikami D, Mano T, Suzumura A. Age-related influences of leg vein filling and emptying on blood volume redistribution and sympathetic reflex during lower body negative pressure in humans. Japanese Journal of Physiology  52: 77-84, 2002.
31. Fu Q, Iwase S, Niimi Y, Kamiya A, Michikami D, Mano T, Suzumura A. Age-related changes in vasomotor reflex control of calf venous capacitance response to lower body negative pressure in humans.  Japanese Journal of Physiology 52: 69-76, 2002.
32. Iwase S, Mano T, Kamiya A, Niimi Y, Fu Q, Suzumura A. Syncopal attack alters the burst properties of muscle sympathetic nerve activity in humans. Autonomic Neuroscience: Basic and Clinic 95: 141-145, 2002.
33. Fu Q, Iwase S, Niimi Y, Kamiya A, Kawanokuchi J, Cui J, Mano T, Suzumura A. Effects of lower body positive pressure on muscle sympathetic nerve activity response to head-up tilt. American Journal of Physiology Regulatory, Integrative and Comparative Physiology 281: R778-R785, 2001.
34. Iwase S, Okamoto T, Mano T, Kamiya A,  Niimi Y, Fu Q, Nishikimi N, Sakurai T, Nimura Y. Skin sympathetic outflow in Buerger’s disease.  Autonomic Neuroscience: Basic and Clinic  87: 286-292, 2001.
35. Kamiya A, Iwase S, Michikami D, Fu Q, and Mano T. Static handgrip exercise modifies arterial baroreflex control of vascular sympathetic outflow in humans. American Journal of Physiology Regulatory, Integrative and Comparative Physiology 281: R1134-1139, 2001.
36. Michikami D, Kamiya A, Fu Q, Iwase S, and Mano T. Effect of local plantar heating on sympathetic nerve activity and core temperature in humans. Autonomic Neuroscience: Basic and Clinic 91: 55-61, 2001.
37. Michikami D, Kamiya A, Fu Q, Niimi Y, Iwase S, Mano T, and Suzumura A. Effect of simulated microgravity exposure on thermoregulatory control of sweating. Environmental Medicine 45: 58-61, 2001.
38. Kawanokuchi J, Fu Q, Cui J, Niimi Y, Kamiya A, Michikami D, Iwase S, Mano T, and Suzumura A. Influence of vestibulo-sympathetic reflex on muscle sympathetic outflow during head-down tilt. Environmental Medicine 45: 66-68, 2001.
39. Fu Q, Sugiyama Y, Kamiya A, and Mano T. A comparison of autonomic responses in humans induced by two simulated models of weightlessness: lower body positive pressure and 6° head-down tilt. Journal of Autonomic Nervous System 80: 101-107, 2000.
40. Fu Q, Iwase S, Kamiya A, Michikami D, Niimi Y, Mano T. Leg venous compliance in orthostatic intolerance before and after 14-day head-down bed. Environmental Medicine 44: 53-55, 2000.
41. Fu Q, Iwase S, Kamiya A, Michikami D, Niimi Y, and Mano T. Regulation of the venous capacitance during microgravity. Journal of Gravitational Physiology 7: 19-22, 2000.
42. Fu Q, Iwase S, Niimi Y, Kamiya A, Michikami D, and Mano T. Effects of leg venous hemodynamics on cardiovascular responses to lower body negative pressure and aging. Journal of Gravitational Physiology 7: 161-162, 2000.
43. Cui J, Iwase S, Mano T, Niimi Y, Fu Q, Michikami D, Atsuta A,, Kamiya A, and Usui H. Body temperature and skin blood flow during a 14-day bed –rest in a head-down tilt position in humans. Journal of Gravitational Physiology 7: 133-134, 2000.
44. Niimi Y, Iwase S, Fu Q, Kamiya A, and Mano T. Effect of aging on muscle sympathetic nerve activity and peripheral venous pressure in humans. Environmental Medicine 44: 56-59, 2000.
45. Kamiya A, Iwase S, Michikami D, Fu Q, and Mano T. Muscle sympathetic nerve activity during handgrip and post-handgrip ischemia after exposure to simulated microgravity in humans. Neuroscience Letters 280: 49-52, 2000.
46. Kamiya A, Iwase S, Michikami D, Fu Q, Mano T, Kitaichi K, and Takagi K. Increased vasomotor sympathetic nerve activity and decreased plasma nitric oxide release after head-down bed rest in humans: disappearance of correlation between vasoconstrictor and vasodilator. Neuroscience Letters 281: 21-24, 2000.
47. Kamiya A, Iwase S, Michikami D, Fu Q, and Mano T. Head-down bed rest alters sympathetic and cardiovascular responses to mental stress. American Journal of Physiology Regulatory, Integrative and Comparative Physiology 279: R440-R447, 2000.
48. Iwase S, Yamamoto K, Miwa C, Kamiya A, Niimi Y, Fu Q, and Mano T. Skin sympathetic neuroeffector response is attenuated dose-dependently by systemic prostaglandin E1 injection in humans. Neuroscience Letters 292: 191-194, 2000.
49. Michikami D, Kamiya A, Fu Q, Niimi Y, Iwase S, and Mano T. Arm elevation enhances muscle sympathetic nerve activity during static exercise. Environmental Medicine 44: 46-48, 2000.
50. Kamiya A, Michikami D, Fu Q, Niimi Y, and Iwase S. Muscle sympathetic nerve activity (MSNA) during high-intensity, isometric leg exercise in humans. Environmental Medicine 44: 49-52, 2000.
51. Kamiya A, Michikami D, Fu Q, Niimi Y, Iwase S, and Mano T. Arterial baroreflex control of sympathetic vasoconstrictor traffic and orthostatic intolerance after head-down bed rest. Journal of Gravitational Physiology 7: 177-178, 2000.
52. Michikami D, Kamiya A, Fu Q, Cui J, Usui H, Atsuta S, Niimi Y, Iwase S, and Mano T. Responses of muscle sympathetic nerve activity to static handgrip exercise after 14 days of exposure to simulated microgravity. Journal of Gravitational Physiology 7: 175-176, 2000.
53. Atsuta S, Kamiya A, Michikami D, Fu Q, Usui H, Niimi Y, Iwase S, and  Mano T. Muscle atrophy and autonomic response to exercise after microgravity exposure. Space Utilization Research 16: 42-44, 2000.
54.  Kamiya A, Michikami D, Fu Q, Atsuta S, Usui H, Niimi Y, Iwase S, and Mano T. Orthostatic intolerance and vasomotor sympathetic nerve activity after microgravity. Space Utilization Research 16: 45-48, 2000.
55. Niimi Y, Iwase S, Fu Q, Kamiya A, Michikami D, Cui J, and Mano T. Effects of aging on muscle sympathetic nerve activity and venous response during lower body negative pressure. Space Utilization Research 16: 49-50, 2000.
56. Michikami D, Kamiya A, Fu Q, Iwase S, and Mano T. Effect of local plantar heating on core temperature in humans. Environmental Medicine 43: 146-149, 1999.
57. Kamiya A, Michikami D, Fu Q, Iwase S, and Mano T. Sympathetic vasoconstriction and orthostatic intolerance after simulated microgravity. Journal of Gravitational Physiology 6: 101-102, 1999.
58. Kamiya A, Michikami D, Fu Q, Iwase S, and Mano T. Vasomotor sympathetic nerve response to static handgrip after simulated microgravity. Journal of Gravitational Physiology 6: 153-154, 1999.
59. Fu Q, Iwase S, Niimi Y, Kamiya A, Michikami D, and Mano T. Effects of aging on leg vein filling and venous compliance during low levels of lower body negative pressure in humans. Environmental Medicine 43: 142-145, 1999.
60. Fu Q, Sugiyama Y, Kamiya A, and Mano T. A comparison of the effects of lower body positive pressure and head-down tilt on cardiovascular responses in humans. Journal of Gravitational Physiology 6: 111-112, 1999.
61. Michikami D, Kamiya A, Fu Q, Iwase S, Minato K, and Mano T. Effect of local plantar heating on core temperature and skin sympathetic nerve activity in humans. The Autonomic Nervous System 36: 552-563, 1999 (in Japanese with English abstract).
62.  Fu Q, Sugiyama Y, Kamiya A, Shamsuzzaman AS, and Mano T. Responses of muscle sympathetic nerve activity to lower body positive pressure. American Journal of Physiology Heart and Circulatory Physiology 275: H1254-H1259, 1998.
63. Fu Q, Sugiyama Y, Kamiya A, Shamsuzzaman AS, and Mano T. Effects of lower body positive pressure on muscle sympathetic nerve activity. Environmental Medicine 42: 76-78, 1998.
64. Shamsuzzaman AS, Sugiyama Y, Kamiya A, Fu Q, and Mano T. Head-up suspension in humans: effects on sympathetic vasomotor activity and cardiovascular responses. Journal of Applied Physiology 84: 1513-1519, 1998.
65. Fu Q, Zhang Z, and Bao S. The role of leukocyte in cerebrovascular diseases (added 42 clinical cases analysis). Clinical Neurology 5: 224-228, 1996 (in Chinese).
66. Fu Q, Bao S, and Liu C. Responses of microglia and leukocyte to experimental cerebral ischemia and reperfusion in rats. Jiangsu Medicine 8: 36-39, 1996 (in Chinese).
67. Fu Q and Bao S. Influences of activated leukocytes on cerebrovascular diseases in humans. Oversea Medicine 2: 160-162, 1994 (in Chinese).
68. Liu C, Fu Q, and Bao S. Assessment of cerebral circulation on internal carotid occlusion patients by Transcranial Doppler. Chinese Journal of Medical Imaging Technology 9: 23-24, 1993 (in Chinese).
69. Fu Q and Bao S. Focal headache caused by complete anterior and middle cerebral artery occlusion. Oversea Medicine 4: 212-213, 1992 (in Chinese).
70. Fu Q, Liu C, and Bao S. Effects of nimodipine on acute cerebral ischemia in humans. Oversea Medicine 2: 116-117, 1991 (in Chinese).

Ongoing Support:

Grant #1K23HL075283-01

Fu (PI)
4/15/04 - 3/31/09
National Heart Lung and Blood Institute
"Gender & orthostatic intolerance: mechanisms and therapy"
The purpose of this study is to perform work to know whether gender-specific factors such as the menstrual cycle or physical factors influencing cardiac size and function are among the determinants for orthostatic intolerance in young women, and whether exercise training can be considered an effective non-pharmacologic measure for patients to improve their orthostatic tolerance.
Role: PI

Completed Support:

Grant #02250174Y
Fu (PI)
7/1/2002 - 6/30/2004
American Heart Association - Texas Affiliate Fellowship Award
"Vasoconstrictor Reserve: A Mechanism for Individual Variability in Orthostatic Intolerance?"
The purpose of this research is to perform work to test the hypotheses that each human individual has a finite range of vasoconstrictor reserve that can be mediated by adrenergic activity, and a limited vasoconstrictor reserve is related to orthostatic intolerance both under normovolemia and hypovolemia conditions.
Role: PI